This gene encodes a mitochondrial transmembrane protein which is a component of the mitochondrial complex I assembly complex. The encoded protein serves as an assembly factor that is required for formation of the membrane arm of the complex. It interacts with NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 13. Naturally occurring mutations in this gene are associated with isolated complex I deficiency. A pseudogene of this gene has been defined on chromosome 9. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for TMEM126B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM126B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM126B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:84,719,746–84,721,467 | 907.7 kb | Distal (>10kb) Multiome HiCAR | 359 | |
| chr11:85,539,822–85,540,935 | 88.5 kb | Distal (>10kb) Multiome | 130 | |
| chr11:85,627,372–85,629,061 | 137 bp | At TSS Multiome | 826 | |
| chr11:85,647,447–85,648,443 | 19.4 kb | Distal (>10kb) Multiome | 808 | |
| chr11:85,663,762–85,665,466 | 36.5 kb | Distal (>10kb) Multiome | 999 | |
| chr11:85,809,696–85,811,885 | 182.6 kb | Distal (>10kb) Multiome | 535 | |
| chr11:85,854,605–85,855,812 | 226.5 kb | Distal (>10kb) Multiome | 948 | |
| chr11:86,244,135–86,246,099 | 616.4 kb | Distal (>10kb) Multiome HiCAR | 959 |
Genomic view of the TMEM126B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.