Predicted to be involved in several processes, including cellular response to brain-derived neurotrophic factor stimulus; nervous system development; and regulation of signal transduction. Predicted to be located in somatodendritic compartment. Predicted to be active in several cellular components, including endosome; glutamatergic synapse; and postsynaptic density membrane. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TMEM108. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM108 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM108, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:132,721,513–132,723,554 | 315.7 kb | Distal (>10kb) Multiome HiCAR | 756 | |
| chr3:133,037,636–133,039,245 | 76 bp | At TSS Multiome | 446 | |
| chr3:133,040,853–133,041,710 | 2.5 kb | Proximal (<10kb) | 174 | |
| chr3:133,327,859–133,328,993 | 290.2 kb | Distal (>10kb) Multiome | 143 | |
| chr3:133,384,300–133,384,776 | 346.2 kb | Distal (>10kb) Multiome HiCAR | 247 |
Genomic view of the TMEM108 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.