Predicted to be located in endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM106C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM106C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM106C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:47,705,453–47,706,210 | 257.7 kb | Distal (>10kb) Multiome | 859 | |
| chr12:47,717,388–47,718,196 | 245.8 kb | Distal (>10kb) Multiome | 330 | |
| chr12:47,757,825–47,759,674 | 204.4 kb | Distal (>10kb) Multiome | 644 | |
| chr12:47,772,964–47,774,017 | 190.3 kb | Distal (>10kb) Multiome | 568 | |
| chr12:47,778,984–47,779,897 | 184.1 kb | Distal (>10kb) Multiome | 320 | |
| chr12:47,812,831–47,813,817 | 150.5 kb | Distal (>10kb) Multiome | 555 | |
| chr12:47,818,868–47,821,142 | 143.6 kb | Distal (>10kb) Multiome | 777 | |
| chr12:47,904,573–47,905,755 | 58.4 kb | Distal (>10kb) Multiome | 575 | |
| chr12:47,942,159–47,942,641 | 21.1 kb | Distal (>10kb) Multiome | 160 | |
| chr12:47,963,134–47,964,083 | 39 bp | At TSS Multiome | 742 | |
| chr12:48,000,982–48,002,307 | 38.0 kb | Distal (>10kb) Multiome | 379 | |
| chr12:48,003,968–48,005,434 | 41.0 kb | Distal (>10kb) Multiome | 366 | |
| chr12:48,021,709–48,022,295 | 58.3 kb | Distal (>10kb) Multiome | 419 | |
| chr12:48,023,364–48,024,084 | 60.0 kb | Distal (>10kb) Multiome | 188 | |
| chr12:48,037,309–48,037,998 | 74.0 kb | Distal (>10kb) Multiome | 157 | |
| chr12:48,105,562–48,106,521 | 142.5 kb | Distal (>10kb) Multiome | 962 | |
| chr12:48,118,916–48,119,822 | 155.7 kb | Distal (>10kb) Multiome | 486 | |
| chr12:48,156,989–48,157,958 | 194.0 kb | Distal (>10kb) Multiome | 767 | |
| chr12:48,183,072–48,184,156 | 219.9 kb | Distal (>10kb) Multiome | 407 | |
| chr12:48,197,601–48,198,835 | 234.6 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the TMEM106C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.