Predicted to be involved in several processes, including positive regulation of intracellular signal transduction; positive regulation of macromolecule biosynthetic process; and positive regulation of nitric oxide metabolic process. Predicted to be located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM106A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM106A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM106A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,964,237–42,964,843 | 247.4 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 231.4 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 213.6 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 189.5 kb | Distal (>10kb) Multiome HiCAR | 973 | |
| chr17:43,024,255–43,025,752 | 186.9 kb | Distal (>10kb) Multiome HiCAR | 811 | |
| chr17:43,124,981–43,125,702 | 86.4 kb | Distal (>10kb) Multiome | 837 | |
| chr17:43,169,744–43,171,576 | 40.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr17:43,211,494–43,212,392 | 60 bp | At TSS Multiome | 586 | |
| chr17:43,359,784–43,361,254 | 149.2 kb | Distal (>10kb) Multiome | 981 | |
| chr17:43,367,132–43,369,458 | 157.3 kb | Distal (>10kb) Multiome | 1146 | |
| chr17:43,388,101–43,389,658 | 177.5 kb | Distal (>10kb) Multiome | 770 | |
| chr17:43,396,555–43,396,987 | 184.9 kb | Distal (>10kb) Multiome | 27 | |
| chr17:43,398,359–43,400,469 | 187.0 kb | Distal (>10kb) Multiome | 827 | |
| chr17:43,403,154–43,404,714 | 192.1 kb | Distal (>10kb) Multiome | 252 | |
| chr17:43,406,748–43,407,604 | 195.3 kb | Distal (>10kb) Multiome | 102 | |
| chr17:43,438,695–43,439,408 | 227.1 kb | Distal (>10kb) Multiome | 86 | |
| chr17:43,457,977–43,459,063 | 246.6 kb | Distal (>10kb) Multiome | 328 | |
| chr17:43,483,594–43,484,268 | 272.0 kb | Distal (>10kb) Multiome | 1016 |
Genomic view of the TMEM106A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.