Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM104. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM104 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM104, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:74,642,311–74,642,966 | 133.6 kb | Distal (>10kb) Multiome | 119 | |
| chr17:74,643,823–74,644,224 | 132.3 kb | Distal (>10kb) Multiome | 17 | |
| chr17:74,671,047–74,671,700 | 105.1 kb | Distal (>10kb) Multiome | 938 | |
| chr17:74,736,296–74,738,156 | 39.1 kb | Distal (>10kb) Multiome | 797 | |
| chr17:74,744,666–74,745,585 | 31.7 kb | Distal (>10kb) Multiome | 580 | |
| chr17:74,745,827–74,747,102 | 29.9 kb | Distal (>10kb) Multiome | 213 | |
| chr17:74,748,109–74,749,683 | 28.0 kb | Distal (>10kb) Multiome | 915 | |
| chr17:74,770,794–74,771,004 | 5.5 kb | Proximal (<10kb) | 467 | |
| chr17:74,775,871–74,776,940 | 138 bp | At TSS Multiome | 798 | |
| chr17:74,842,511–74,843,541 | 66.5 kb | Distal (>10kb) Multiome | 412 | |
| chr17:74,852,259–74,853,211 | 76.1 kb | Distal (>10kb) Multiome | 435 | |
| chr17:74,872,506–74,873,926 | 96.7 kb | Distal (>10kb) Multiome | 1008 | |
| chr17:74,893,600–74,894,183 | 117.3 kb | Distal (>10kb) Multiome | 189 | |
| chr17:74,923,198–74,923,804 | 147.1 kb | Distal (>10kb) Multiome | 543 | |
| chr17:74,972,019–74,973,116 | 196.2 kb | Distal (>10kb) Multiome | 607 | |
| chr17:74,982,006–74,982,936 | 205.9 kb | Distal (>10kb) Multiome | 952 | |
| chr17:74,987,081–74,988,770 | 211.1 kb | Distal (>10kb) Multiome | 702 | |
| chr17:75,012,158–75,013,285 | 236.2 kb | Distal (>10kb) Multiome | 1058 | |
| chr17:75,033,550–75,035,757 | 258.6 kb | Distal (>10kb) Multiome | 1228 | |
| chr17:75,046,451–75,047,855 | 270.6 kb | Distal (>10kb) Multiome | 961 |
Genomic view of the TMEM104 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.