Involved in regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling pathway; response to cytokine; and signal transduction. Acts upstream of or within positive regulation of T cell migration and positive regulation of cell adhesion. Located in cell surface. Part of protein-containing complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM102. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM102 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM102, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:7,177,263–7,177,909 | 257.9 kb | Distal (>10kb) Multiome | 453 | |
| chr17:7,204,820–7,205,551 | 230.3 kb | Distal (>10kb) Multiome | 364 | |
| chr17:7,207,943–7,208,476 | 227.2 kb | Distal (>10kb) Multiome | 91 | |
| chr17:7,213,858–7,216,461 | 221.0 kb | Distal (>10kb) Multiome | 737 | |
| chr17:7,219,603–7,220,515 | 215.5 kb | Distal (>10kb) Multiome | 793 | |
| chr17:7,233,847–7,235,210 | 200.9 kb | Distal (>10kb) Multiome | 1020 | |
| chr17:7,237,531–7,238,757 | 197.5 kb | Distal (>10kb) Multiome | 502 | |
| chr17:7,238,867–7,240,155 | 195.8 kb | Distal (>10kb) Multiome | 783 | |
| chr17:7,241,494–7,243,462 | 193.0 kb | Distal (>10kb) Multiome | 1037 | |
| chr17:7,251,263–7,252,962 | 183.3 kb | Distal (>10kb) Multiome | 985 | |
| chr17:7,260,746–7,263,748 | 172.8 kb | Distal (>10kb) Multiome | 639 | |
| chr17:7,280,161–7,282,555 | 153.8 kb | Distal (>10kb) Multiome | 841 | |
| chr17:7,293,901–7,295,189 | 140.7 kb | Distal (>10kb) Multiome | 443 | |
| chr17:7,296,224–7,296,683 | 138.9 kb | Distal (>10kb) Multiome | 688 | |
| chr17:7,306,788–7,309,027 | 128.0 kb | Distal (>10kb) Multiome | 896 | |
| chr17:7,314,722–7,315,725 | 120.1 kb | Distal (>10kb) Multiome | 843 | |
| chr17:7,328,881–7,330,972 | 105.1 kb | Distal (>10kb) Multiome | 809 | |
| chr17:7,349,378–7,350,590 | 85.2 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,351,208–7,352,575 | 83.4 kb | Distal (>10kb) Multiome | 857 | |
| chr17:7,356,082–7,356,523 | 79.2 kb | Distal (>10kb) Multiome | 485 | |
| chr17:7,383,791–7,384,537 | 51.2 kb | Distal (>10kb) Multiome | 218 | |
| chr17:7,393,924–7,395,223 | 40.8 kb | Distal (>10kb) Multiome | 744 | |
| chr17:7,403,290–7,405,695 | 31.1 kb | Distal (>10kb) Multiome | 838 | |
| chr17:7,435,167–7,437,681 | 26 bp | At TSS Multiome | 828 | |
| chr17:7,437,892–7,438,555 | 2.5 kb | Proximal (<10kb) | 224 | |
| chr17:7,440,048–7,441,211 | 5.3 kb | Proximal (<10kb) Multiome | 487 | |
| chr17:7,444,968–7,446,142 | 10.1 kb | Distal (>10kb) Multiome | 632 | |
| chr17:7,455,450–7,456,019 | 20.2 kb | Distal (>10kb) Multiome | 414 | |
| chr17:7,478,839–7,480,126 | 44.0 kb | Distal (>10kb) Multiome | 574 | |
| chr17:7,483,139–7,485,576 | 49.0 kb | Distal (>10kb) Multiome | 1156 | |
| chr17:7,560,249–7,562,536 | 126.5 kb | Distal (>10kb) Multiome | 759 | |
| chr17:7,572,039–7,574,418 | 137.2 kb | Distal (>10kb) Multiome | 1071 | |
| chr17:7,579,018–7,579,876 | 144.0 kb | Distal (>10kb) Multiome | 844 | |
| chr17:7,583,063–7,584,547 | 148.3 kb | Distal (>10kb) Multiome | 921 | |
| chr17:7,588,871–7,590,534 | 154.8 kb | Distal (>10kb) Multiome | 319 | |
| chr17:7,614,065–7,615,780 | 179.7 kb | Distal (>10kb) Multiome | 708 | |
| chr17:7,627,090–7,628,247 | 192.4 kb | Distal (>10kb) Multiome | 712 | |
| chr17:7,650,010–7,652,127 | 215.3 kb | Distal (>10kb) Multiome | 467 | |
| chr17:7,685,876–7,686,907 | 250.9 kb | Distal (>10kb) Multiome | 765 | |
| chr17:7,687,214–7,687,777 | 252.1 kb | Distal (>10kb) Multiome | 710 | |
| chr17:7,687,867–7,688,863 | 252.9 kb | Distal (>10kb) Multiome | 700 | |
| chr17:7,703,383–7,703,975 | 268.2 kb | Distal (>10kb) Multiome | 141 | |
| chr17:7,704,799–7,705,590 | 269.7 kb | Distal (>10kb) Multiome | 325 | |
| chr17:7,716,832–7,717,983 | 281.9 kb | Distal (>10kb) Multiome | 759 |
Genomic view of the TMEM102 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.