Enables receptor ligand inhibitor activity. Involved in host-mediated suppression of symbiont invasion. Is active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEFF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEFF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEFF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:100,352,182–100,353,419 | 120.2 kb | Distal (>10kb) Multiome | 937 | |
| chr9:100,411,250–100,412,233 | 61.4 kb | Distal (>10kb) Multiome | 544 | |
| chr9:100,426,556–100,428,087 | 45.8 kb | Distal (>10kb) Multiome | 680 | |
| chr9:100,469,038–100,469,336 | 3.8 kb | Proximal (<10kb) | 55 | |
| chr9:100,472,600–100,475,134 | 44 bp | At TSS Multiome | 501 | |
| chr9:100,567,051–100,567,983 | 94.3 kb | Distal (>10kb) Multiome | 147 | |
| chr9:100,598,220–100,599,238 | 125.7 kb | Distal (>10kb) Multiome | 517 | |
| chr9:100,637,622–100,638,453 | 164.8 kb | Distal (>10kb) Multiome | 112 | |
| chr9:100,664,438–100,664,921 | 191.6 kb | Distal (>10kb) Multiome | 46 |
Genomic view of the TMEFF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.