Predicted to be involved in Golgi organization; endoplasmic reticulum to Golgi vesicle-mediated transport; and intracellular protein transport. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMED7. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMED7 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMED7, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr5:115,384,667–115,385,510 | 240.9 kb | Distal (>10kb) Multiome | 108 | |
| chr5:115,543,835–115,545,478 | 81.2 kb | Distal (>10kb) Multiome | 943 | |
| chr5:115,601,724–115,602,813 | 23.9 kb | Distal (>10kb) Multiome | 542 | |
| chr5:115,625,502–115,626,687 | 121 bp | At TSS Multiome | 976 | |
| chr5:115,634,444–115,635,004 | 8.4 kb | Proximal (<10kb) | 396 | |
| chr5:115,785,567–115,786,155 | 159.8 kb | Distal (>10kb) Multiome | 90 | |
| chr5:115,815,539–115,817,207 | 190.6 kb | Distal (>10kb) Multiome | 490 | |
| chr5:115,840,887–115,842,729 | 215.8 kb | Distal (>10kb) Multiome | 1077 |
Genomic view of the TMED7 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.