Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in several cellular components, including COPII-coated ER to Golgi transport vesicle; Golgi apparatus; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMED4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMED4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMED4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:44,309,084–44,310,124 | 272.4 kb | Distal (>10kb) Multiome | 263 | |
| chr7:44,325,052–44,325,687 | 256.8 kb | Distal (>10kb) Multiome | 118 | |
| chr7:44,490,144–44,491,030 | 91.5 kb | Distal (>10kb) Multiome | 996 | |
| chr7:44,573,627–44,574,398 | 8.2 kb | Proximal (<10kb) Multiome | 885 | |
| chr7:44,581,475–44,583,147 | 151 bp | At TSS Multiome | 864 | |
| chr7:44,606,125–44,607,487 | 24.6 kb | Distal (>10kb) Multiome | 1043 | |
| chr7:44,748,085–44,749,703 | 166.4 kb | Distal (>10kb) Multiome HiCAR | 665 | |
| chr7:44,795,796–44,797,747 | 214.3 kb | Distal (>10kb) Multiome HiCAR | 1094 | |
| chr7:44,847,376–44,848,800 | 266.0 kb | Distal (>10kb) Multiome | 990 | |
| chr7:44,884,668–44,886,169 | 303.4 kb | Distal (>10kb) Multiome HiCAR | 956 | |
| chr7:44,962,460–44,963,298 | 380.7 kb | Distal (>10kb) Multiome HiCAR | 179 |
Genomic view of the TMED4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.