Predicted to enable calcium channel activity. Involved in negative regulation of apoptotic process and regulation of calcium-mediated signaling. Located in Golgi stack and endoplasmic reticulum membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMBIM4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMBIM4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMBIM4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:65,897,482–65,897,992 | 271.8 kb | Distal (>10kb) Multiome | 129 | |
| chr12:65,925,832–65,927,041 | 243.1 kb | Distal (>10kb) Multiome | 384 | |
| chr12:66,061,688–66,062,514 | 107.4 kb | Distal (>10kb) Multiome | 137 | |
| chr12:66,169,293–66,170,152 | 258 bp | At TSS Multiome | 1068 | |
| chr12:66,188,883–66,189,740 | 19.8 kb | Distal (>10kb) Multiome | 387 | |
| chr12:66,235,081–66,235,617 | 65.8 kb | Distal (>10kb) Multiome | 221 | |
| chr12:66,301,849–66,302,942 | 133.0 kb | Distal (>10kb) Multiome | 756 |
Genomic view of the TMBIM4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.