Enables identical protein binding activity. Involved in regulation of lipid metabolic process. Located in endoplasmic reticulum membrane and endoplasmic reticulum-Golgi intermediate compartment membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TM6SF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TM6SF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TM6SF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:19,017,061–19,017,561 | 256.0 kb | Distal (>10kb) Multiome | 21 | |
| chr19:19,032,820–19,034,059 | 239.6 kb | Distal (>10kb) Multiome | 944 | |
| chr19:19,063,253–19,064,386 | 209.5 kb | Distal (>10kb) Multiome | 781 | |
| chr19:19,105,310–19,106,514 | 167.5 kb | Distal (>10kb) Multiome | 447 | |
| chr19:19,119,998–19,121,362 | 152.7 kb | Distal (>10kb) Multiome | 304 | |
| chr19:19,138,171–19,138,698 | 134.8 kb | Distal (>10kb) Multiome | 642 | |
| chr19:19,170,055–19,170,692 | 102.9 kb | Distal (>10kb) Multiome | 403 | |
| chr19:19,191,912–19,193,209 | 80.7 kb | Distal (>10kb) Multiome | 939 | |
| chr19:19,202,895–19,203,773 | 69.8 kb | Distal (>10kb) Multiome | 599 | |
| chr19:19,224,938–19,225,553 | 48.0 kb | Distal (>10kb) Multiome | 646 | |
| chr19:19,261,403–19,261,973 | 11.6 kb | Distal (>10kb) Multiome | 205 | |
| chr19:19,272,869–19,273,464 | 110 bp | At TSS Multiome | 236 | |
| chr19:19,320,030–19,321,531 | 47.4 kb | Distal (>10kb) Multiome | 839 | |
| chr19:19,384,944–19,386,424 | 112.3 kb | Distal (>10kb) Multiome | 788 | |
| chr19:19,405,072–19,406,890 | 132.4 kb | Distal (>10kb) Multiome | 1014 | |
| chr19:19,461,886–19,462,726 | 189.1 kb | Distal (>10kb) Multiome | 345 | |
| chr19:19,515,735–19,516,510 | 242.9 kb | Distal (>10kb) Multiome | 824 | |
| chr19:19,532,119–19,532,674 | 259.1 kb | Distal (>10kb) Multiome | 405 | |
| chr19:19,538,087–19,538,726 | 265.1 kb | Distal (>10kb) Multiome | 255 | |
| chr19:19,539,681–19,541,846 | 268.1 kb | Distal (>10kb) Multiome | 352 |
Genomic view of the TM6SF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.