This gene encodes a protein that is regulated by micro RNA MiR-574-3, and is thought to have an oncogenic function in human bladder cancer. A similar gene in mouse is located in a chromosomal region critical for differentiation of mesoderm, which affects embryo patterning and the formation of heart, muscle, blood, skeleton and the urogenital system. The mouse gene is expressed in early development, and in the adult. [provided by RefSeq, Nov 2016]
Transcription factors with Perturb-seq knockdown data for TLNRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLNRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLNRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:80,778,964–80,780,209 | 221.7 kb | Distal (>10kb) Multiome | 528 | |
| chr15:80,780,345–80,780,949 | 220.2 kb | Distal (>10kb) Multiome | 676 | |
| chr15:80,989,298–80,990,315 | 11.1 kb | Distal (>10kb) Multiome | 780 | |
| chr15:81,000,317–81,003,329 | 18 bp | At TSS Multiome | 865 | |
| chr15:81,133,906–81,134,755 | 133.3 kb | Distal (>10kb) Multiome | 230 |
Genomic view of the TLNRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.