This gene encodes an astacin-like zinc-dependent metalloprotease and is a subfamily member of the metzincin family. Unlike other family members, a similar protein in mice does not cleave procollagen C-propeptides or chordin. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TLL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:96,309,703–96,310,258 | 203.9 kb | Distal (>10kb) Multiome | 187 | |
| chr10:96,375,112–96,375,818 | 138.5 kb | Distal (>10kb) Multiome HiCAR | 477 | |
| chr10:96,509,174–96,509,560 | 4.4 kb | Proximal (<10kb) | 66 | |
| chr10:96,511,266–96,511,541 | 2.4 kb | Proximal (<10kb) | 100 | |
| chr10:96,512,627–96,512,987 | 930 bp | At TSS | 201 | |
| chr10:96,513,081–96,514,568 | 29 bp | At TSS Multiome | 703 | |
| chr10:96,586,308–96,587,486 | 73.1 kb | Distal (>10kb) Multiome | 840 | |
| chr10:96,719,871–96,720,167 | 206.2 kb | Distal (>10kb) Multiome | 395 | |
| chr10:96,720,285–96,721,494 | 206.9 kb | Distal (>10kb) Multiome | 522 |
Genomic view of the TLL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.