Enables DNA-binding transcription factor binding activity; identical protein binding activity; and transcription corepressor activity. Involved in negative regulation of anoikis; negative regulation of signal transduction; and regulation of gene expression. Located in cytosol and nucleoplasm. Part of beta-catenin-TCF complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TLE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:80,619,152–80,619,931 | 1070.0 kb | Distal (>10kb) Multiome HiCAR | 70 | |
| chr9:81,557,995–81,559,249 | 130.9 kb | Distal (>10kb) Multiome HiCAR | 203 | |
| chr9:81,595,970–81,596,583 | 93.2 kb | Distal (>10kb) Multiome | 159 | |
| chr9:81,596,729–81,597,672 | 92.2 kb | Distal (>10kb) Multiome | 126 | |
| chr9:81,621,323–81,623,097 | 67.5 kb | Distal (>10kb) Multiome | 347 | |
| chr9:81,680,060–81,681,322 | 8.8 kb | Proximal (<10kb) Multiome | 157 | |
| chr9:81,686,886–81,690,867 | 229 bp | At TSS Multiome | 1031 | |
| chr9:81,737,691–81,739,270 | 48.8 kb | Distal (>10kb) Multiome | 355 | |
| chr9:81,814,081–81,816,531 | 126.5 kb | Distal (>10kb) Multiome HiCAR | 504 |
Genomic view of the TLE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.