Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TLCD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,039,936–120,040,648 | 285.0 kb | Distal (>10kb) Multiome | 29 | |
| chr11:120,057,897–120,058,380 | 267.1 kb | Distal (>10kb) Multiome | 90 | |
| chr11:120,168,771–120,169,627 | 156.1 kb | Distal (>10kb) Multiome | 478 | |
| chr11:120,210,679–120,211,521 | 114.4 kb | Distal (>10kb) Multiome | 606 | |
| chr11:120,236,598–120,237,182 | 88.5 kb | Distal (>10kb) Multiome | 249 | |
| chr11:120,255,150–120,255,776 | 69.8 kb | Distal (>10kb) Multiome | 143 | |
| chr11:120,324,948–120,325,789 | 29 bp | At TSS Multiome | 665 | |
| chr11:120,334,912–120,335,251 | 9.6 kb | Proximal (<10kb) | 294 | |
| chr11:120,335,703–120,337,153 | 11.0 kb | Distal (>10kb) Multiome | 976 | |
| chr11:120,510,928–120,512,148 | 186.2 kb | Distal (>10kb) Multiome | 448 | |
| chr11:120,527,165–120,527,924 | 202.2 kb | Distal (>10kb) Multiome | 168 | |
| chr11:120,564,037–120,565,284 | 238.8 kb | Distal (>10kb) Multiome | 254 |
Genomic view of the TLCD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.