This gene encodes a transmembrane protein, which may be a likely target of peroxisome proliferator-activated receptor gamma (PPAR-gamma). The product of the orthologous gene in mouse is related to obesity. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]
Transcription factors with Perturb-seq knockdown data for TLCD3B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD3B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD3B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:29,784,957–29,785,426 | 267.7 kb | Distal (>10kb) Multiome | 452 | |
| chr16:29,790,073–29,791,192 | 262.3 kb | Distal (>10kb) Multiome | 1003 | |
| chr16:29,804,592–29,808,172 | 247.2 kb | Distal (>10kb) Multiome | 1275 | |
| chr16:29,810,746–29,812,649 | 240.6 kb | Distal (>10kb) Multiome | 826 | |
| chr16:29,815,828–29,817,186 | 236.8 kb | Distal (>10kb) Multiome | 1006 | |
| chr16:29,862,597–29,863,901 | 189.5 kb | Distal (>10kb) Multiome | 953 | |
| chr16:29,876,281–29,878,282 | 176.6 kb | Distal (>10kb) Multiome | 319 | |
| chr16:29,899,174–29,900,833 | 153.5 kb | Distal (>10kb) Multiome | 1019 | |
| chr16:29,925,692–29,926,784 | 126.7 kb | Distal (>10kb) Multiome | 912 | |
| chr16:29,961,477–29,962,530 | 91.0 kb | Distal (>10kb) Multiome | 848 | |
| chr16:29,973,238–29,974,906 | 79.3 kb | Distal (>10kb) Multiome | 935 | |
| chr16:29,994,888–29,996,728 | 57.7 kb | Distal (>10kb) Multiome | 1080 | |
| chr16:30,021,215–30,021,860 | 31.4 kb | Distal (>10kb) Multiome | 764 | |
| chr16:30,052,803–30,053,364 | 89 bp | At TSS Multiome | 989 | |
| chr16:30,055,113–30,055,305 | 2.1 kb | Proximal (<10kb) | 344 | |
| chr16:30,063,722–30,066,296 | 12.6 kb | Distal (>10kb) Multiome | 1209 | |
| chr16:30,075,490–30,076,439 | 23.0 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 39.0 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 43.4 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 70.2 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 130.5 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 282.4 kb | Distal (>10kb) Multiome | 486 |
Genomic view of the TLCD3B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.