TIMM9 belongs to a family of evolutionarily conserved proteins that are organized in heterooligomeric complexes in the mitochondrial intermembrane space. These proteins mediate the import and insertion of hydrophobic membrane proteins into the mitochondrial inner membrane.[supplied by OMIM, Apr 2004]
Transcription factors with Perturb-seq knockdown data for TIMM9. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM9 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM9, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:58,151,365–58,152,866 | 275.0 kb | Distal (>10kb) Multiome | 506 | |
| chr14:58,199,683–58,200,642 | 227.1 kb | Distal (>10kb) Multiome | 673 | |
| chr14:58,244,179–58,245,432 | 182.3 kb | Distal (>10kb) Multiome | 789 | |
| chr14:58,297,373–58,299,879 | 128.9 kb | Distal (>10kb) Multiome | 1029 | |
| chr14:58,395,454–58,396,694 | 31.2 kb | Distal (>10kb) Multiome | 791 | |
| chr14:58,426,724–58,428,061 | 493 bp | At TSS Multiome | 996 | |
| chr14:58,625,028–58,626,860 | 198.5 kb | Distal (>10kb) Multiome | 240 | |
| chr14:58,637,252–58,639,111 | 210.7 kb | Distal (>10kb) Multiome | 493 |
Genomic view of the TIMM9 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.