This gene encodes a member of a well-conserved family of proteins with similarity to yeast Tim mitochondrial import proteins. This gene is encoded by a nuclear gene and is transported into the intermembrane space of the mitochondrion. When formed into complexes, these proteins guide membrane-spanning proteins across the mitochondrial intermembrane space before they are added into the mitochondrial inner membrane. This gene is adjacent to succinate dehydrogenase, subunit D (SDHD), in which mutations have been found in affected members of families with hereditary paraganglioma.[provided by RefSeq, Aug 2009]
Transcription factors with Perturb-seq knockdown data for TIMM8B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM8B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM8B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:111,870,839–111,871,692 | 215.5 kb | Distal (>10kb) Multiome | 781 | |
| chr11:111,878,459–111,879,798 | 207.6 kb | Distal (>10kb) Multiome | 970 | |
| chr11:111,918,534–111,919,259 | 167.8 kb | Distal (>10kb) Multiome | 468 | |
| chr11:111,926,372–111,927,689 | 159.7 kb | Distal (>10kb) Multiome | 767 | |
| chr11:111,936,752–111,938,016 | 149.5 kb | Distal (>10kb) Multiome | 671 | |
| chr11:111,960,703–111,961,374 | 125.7 kb | Distal (>10kb) Multiome | 192 | |
| chr11:111,976,357–111,978,029 | 109.6 kb | Distal (>10kb) Multiome | 293 | |
| chr11:111,982,641–111,983,482 | 103.5 kb | Distal (>10kb) Multiome | 290 | |
| chr11:112,024,495–112,025,893 | 61.6 kb | Distal (>10kb) Multiome | 1024 | |
| chr11:112,073,749–112,074,754 | 12.6 kb | Distal (>10kb) Multiome | 828 | |
| chr11:112,086,268–112,087,320 | 27 bp | At TSS Multiome | 883 | |
| chr11:112,225,928–112,226,959 | 139.7 kb | Distal (>10kb) Multiome | 809 | |
| chr11:112,289,677–112,290,832 | 203.5 kb | Distal (>10kb) Multiome | 568 |
Genomic view of the TIMM8B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.