TIMM44

translocase of inner mitochondrial membrane 44 | TIM44

This gene encodes a peripheral membrane protein associated with the mitochondrial inner membrane translocase, which functions in the import of proteins across the mitochondrial inner membrane and into the mitochondrial matrix. The encoded protein mediates binding of mitochondrial heat shock protein 70 to the translocase of inner mitochondrial membrane 23 (TIM23) complex. Expression of this gene is upregulated in kidney in a mouse model of diabetes. A mutation in this gene is associated with familial oncocytic thyroid carcinoma. [provided by RefSeq, Jul 2016]

Member of: DE-1 DE-1.5 Developmental clusters: GC3

Biological processes 18 terms

PAM complex, Tim23 associated import motor (GO:0001405)TIM23 mitochondrial import inner membrane translocase complex (GO:0005744)establishment of protein localization (GO:0045184)intracellular protein transport (GO:0006886)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial inner membrane (GO:0005743)mitochondrial matrix (GO:0005759)mitochondrial matrix (GO:0005759)mitochondrion (GO:0005739)mitochondrion (GO:0005739)protein binding (GO:0005515)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein import into mitochondrial matrix (GO:0030150)protein-folding chaperone binding (GO:0051087)protein-folding chaperone binding (GO:0051087)protein-macromolecule adaptor activity (GO:0030674)

Expression (TPM)

TFs regulating TIMM44 0 TFs

Transcription factors with Perturb-seq knockdown data for TIMM44. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM44 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TIMM44

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM44, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:7,680,480–7,681,546	262.9 kb	Distal (>10kb) Multiome	679
chr19:7,829,238–7,830,666	113.8 kb	Distal (>10kb) Multiome	621
chr19:7,853,168–7,853,781	90.2 kb	Distal (>10kb) Multiome	747
chr19:7,861,607–7,864,383	81.0 kb	Distal (>10kb) Multiome	348
chr19:7,868,454–7,870,252	74.2 kb	Distal (>10kb) Multiome	721
chr19:7,871,072–7,872,772	71.6 kb	Distal (>10kb) Multiome	487
chr19:7,873,962–7,875,061	69.0 kb	Distal (>10kb) Multiome	416
chr19:7,888,334–7,888,798	55.2 kb	Distal (>10kb) Multiome	509
chr19:7,902,730–7,904,931	39.9 kb	Distal (>10kb) Multiome	1000
chr19:7,917,358–7,918,182	25.7 kb	Distal (>10kb) Multiome	316
chr19:7,919,934–7,921,640	23.0 kb	Distal (>10kb) Multiome	802
chr19:7,924,612–7,926,698	18.4 kb	Distal (>10kb) Multiome	766
chr19:7,943,338–7,944,472	171 bp	At TSS Multiome	974
chr19:8,001,954–8,002,874	58.8 kb	Distal (>10kb) Multiome	475
chr19:8,005,202–8,006,197	62.1 kb	Distal (>10kb) Multiome	729
chr19:8,028,908–8,029,518	85.7 kb	Distal (>10kb) Multiome	122
chr19:8,050,174–8,051,154	107.0 kb	Distal (>10kb) Multiome	467
chr19:8,148,316–8,149,986	205.8 kb	Distal (>10kb) Multiome	381
chr19:8,203,277–8,204,384	260.2 kb	Distal (>10kb) Multiome	150
chr19:8,208,086–8,210,178	265.5 kb	Distal (>10kb) Multiome	712

Genome Browser

Genomic view of the TIMM44 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.