This gene encodes a multipass transmembrane protein that forms an integral component of the mitochondrial translocase TIM23 complex. This complex facilitates the transport of mitochondrial proteins from the cytosol across the mitochondrial inner membrane and into the mitochondrion. There is a pseudogene for this gene on chromosome 12. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2013]
Transcription factors with Perturb-seq knockdown data for TIMM17B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM17B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM17B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,597,350–48,598,476 | 299.9 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 221.2 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 201.1 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 160.4 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 95.9 kb | Distal (>10kb) Multiome | 734 | |
| chrX:48,891,080–48,891,988 | 6.0 kb | Proximal (<10kb) Multiome | 525 | |
| chrX:48,897,163–48,898,345 | 149 bp | At TSS Multiome | 672 | |
| chrX:48,911,574–48,912,414 | 14.2 kb | Distal (>10kb) Multiome | 671 | |
| chrX:48,917,179–48,917,999 | 19.7 kb | Distal (>10kb) Multiome | 468 | |
| chrX:48,918,412–48,919,792 | 21.4 kb | Distal (>10kb) Multiome | 693 | |
| chrX:48,957,469–48,959,105 | 60.6 kb | Distal (>10kb) Multiome | 722 | |
| chrX:49,001,538–49,002,676 | 104.6 kb | Distal (>10kb) Multiome | 540 | |
| chrX:49,039,840–49,040,493 | 142.3 kb | Distal (>10kb) Multiome | 436 | |
| chrX:49,042,954–49,044,182 | 145.9 kb | Distal (>10kb) Multiome | 664 | |
| chrX:49,053,328–49,054,050 | 155.9 kb | Distal (>10kb) Multiome | 403 | |
| chrX:49,071,863–49,072,612 | 174.4 kb | Distal (>10kb) Multiome | 107 | |
| chrX:49,073,903–49,074,451 | 176.3 kb | Distal (>10kb) Multiome | 464 | |
| chrX:49,100,885–49,101,855 | 203.5 kb | Distal (>10kb) Multiome | 562 | |
| chrX:49,155,633–49,156,658 | 258.4 kb | Distal (>10kb) Multiome | 524 | |
| chrX:49,163,555–49,164,377 | 266.3 kb | Distal (>10kb) Multiome | 485 | |
| chrX:49,166,140–49,166,713 | 268.7 kb | Distal (>10kb) Multiome | 416 | |
| chrX:49,184,219–49,185,254 | 286.8 kb | Distal (>10kb) Multiome | 389 | |
| chrX:49,186,113–49,186,660 | 288.7 kb | Distal (>10kb) Multiome | 589 | |
| chrX:49,190,730–49,191,899 | 293.4 kb | Distal (>10kb) Multiome | 636 |
Genomic view of the TIMM17B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.