Predicted to contribute to protein transmembrane transporter activity. Predicted to be involved in protein import into mitochondrial matrix. Located in mitochondrial inner membrane and nucleoplasm. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TIMM17A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM17A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM17A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:201,678,604–201,679,421 | 276.5 kb | Distal (>10kb) Multiome | 158 | |
| chr1:201,709,409–201,709,946 | 245.8 kb | Distal (>10kb) Multiome | 258 | |
| chr1:201,739,028–201,740,430 | 215.8 kb | Distal (>10kb) Multiome | 287 | |
| chr1:201,828,821–201,829,863 | 126.3 kb | Distal (>10kb) Multiome | 821 | |
| chr1:201,888,189–201,889,202 | 66.7 kb | Distal (>10kb) Multiome HiCAR | 335 | |
| chr1:201,895,782–201,896,239 | 59.4 kb | Distal (>10kb) Multiome HiCAR | 606 | |
| chr1:201,941,439–201,942,399 | 13.6 kb | Distal (>10kb) Multiome | 508 | |
| chr1:201,946,301–201,946,923 | 8.9 kb | Proximal (<10kb) Multiome | 290 | |
| chr1:201,955,139–201,955,899 | 79 bp | At TSS Multiome | 881 | |
| chr1:201,982,248–201,983,657 | 27.8 kb | Distal (>10kb) Multiome | 875 | |
| chr1:202,007,961–202,008,615 | 52.8 kb | Distal (>10kb) Multiome | 368 | |
| chr1:202,009,428–202,011,367 | 55.0 kb | Distal (>10kb) Multiome | 761 | |
| chr1:202,075,813–202,076,531 | 120.7 kb | Distal (>10kb) Multiome | 418 | |
| chr1:202,101,336–202,102,103 | 146.3 kb | Distal (>10kb) Multiome | 173 | |
| chr1:202,105,597–202,106,270 | 150.4 kb | Distal (>10kb) Multiome | 376 | |
| chr1:202,135,239–202,135,691 | 179.9 kb | Distal (>10kb) Multiome | 193 | |
| chr1:202,143,721–202,144,890 | 188.5 kb | Distal (>10kb) Multiome | 589 | |
| chr1:202,184,705–202,185,268 | 229.4 kb | Distal (>10kb) Multiome | 258 | |
| chr1:202,214,010–202,214,579 | 258.9 kb | Distal (>10kb) Multiome | 215 | |
| chr1:202,235,967–202,236,655 | 280.9 kb | Distal (>10kb) Multiome | 460 | |
| chr1:202,237,030–202,237,425 | 281.8 kb | Distal (>10kb) Multiome | 305 |
Genomic view of the TIMM17A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.