This gene is regulated as part of the p53 tumor suppressor pathway and encodes a protein with sequence similarity to the bisphosphate domain of the glycolytic enzyme that degrades fructose-2,6-bisphosphate. The protein functions by blocking glycolysis and directing the pathway into the pentose phosphate shunt. Expression of this protein also protects cells from DNA damaging reactive oxygen species and provides some protection from DNA damage-induced apoptosis. The 12p13.32 region that includes this gene is paralogous to the 11q13.3 region. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIGAR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIGAR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIGAR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:4,024,691–4,026,063 | 295.5 kb | Distal (>10kb) Multiome | 356 | |
| chr12:4,030,924–4,031,732 | 289.9 kb | Distal (>10kb) Multiome | 478 | |
| chr12:4,164,558–4,165,200 | 156.4 kb | Distal (>10kb) Multiome | 242 | |
| chr12:4,268,849–4,270,098 | 51.7 kb | Distal (>10kb) Multiome | 487 | |
| chr12:4,270,854–4,273,281 | 49.1 kb | Distal (>10kb) Multiome | 648 | |
| chr12:4,273,341–4,274,316 | 47.4 kb | Distal (>10kb) Multiome | 459 | |
| chr12:4,276,737–4,277,243 | 44.2 kb | Distal (>10kb) Multiome | 453 | |
| chr12:4,307,615–4,308,315 | 13.2 kb | Distal (>10kb) Multiome | 391 | |
| chr12:4,320,509–4,321,663 | 122 bp | At TSS Multiome | 743 | |
| chr12:4,441,229–4,442,210 | 120.5 kb | Distal (>10kb) Multiome | 241 | |
| chr12:4,538,204–4,539,165 | 217.5 kb | Distal (>10kb) Multiome | 740 | |
| chr12:4,562,041–4,562,555 | 241.0 kb | Distal (>10kb) Multiome | 486 | |
| chr12:4,604,713–4,605,166 | 283.7 kb | Distal (>10kb) Multiome | 580 |
Genomic view of the TIGAR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.