The protein encoded by this gene is a member of a family of RNA-binding proteins, has three RNA recognition motifs (RRMs), and binds adenine and uridine-rich elements in mRNA and pre-mRNAs of a wide range of genes. It regulates various activities including translational control, splicing and apoptosis. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The different isoforms have been show to function differently with respect to post-transcriptional silencing. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIAL1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIAL1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIAL1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:119,542,175–119,543,695 | 54.1 kb | Distal (>10kb) Multiome | 709 | |
| chr10:119,596,043–119,597,595 | 95 bp | At TSS Multiome | 893 | |
| chr10:119,650,691–119,652,293 | 54.3 kb | Distal (>10kb) Multiome | 828 | |
| chr10:119,660,009–119,660,666 | 63.4 kb | Distal (>10kb) Multiome | 146 | |
| chr10:119,686,526–119,688,685 | 91.3 kb | Distal (>10kb) Multiome | 790 | |
| chr10:119,725,081–119,726,842 | 129.0 kb | Distal (>10kb) Multiome | 818 | |
| chr10:119,817,887–119,819,190 | 221.6 kb | Distal (>10kb) Multiome | 334 | |
| chr10:119,872,104–119,873,627 | 276.0 kb | Distal (>10kb) Multiome | 835 | |
| chr10:119,892,259–119,893,097 | 295.6 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the TIAL1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.