Enables tRNA (guanine(6)-N2)-methyltransferase activity and tRNA (guanine(7)-N2)-methyltransferase activity. Involved in tRNA methylation. Located in cytosol and nucleolus. Part of tRNA methyltransferase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THUMPD3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THUMPD3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THUMPD3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:9,101,985–9,102,991 | 260.5 kb | Distal (>10kb) Multiome | 210 | |
| chr3:9,135,686–9,136,655 | 226.8 kb | Distal (>10kb) Multiome | 201 | |
| chr3:9,158,726–9,159,822 | 203.7 kb | Distal (>10kb) Multiome | 115 | |
| chr3:9,204,163–9,205,101 | 158.5 kb | Distal (>10kb) Multiome | 389 | |
| chr3:9,249,284–9,250,085 | 113.4 kb | Distal (>10kb) Multiome | 452 | |
| chr3:9,302,190–9,302,888 | 60.5 kb | Distal (>10kb) Multiome | 416 | |
| chr3:9,353,240–9,353,446 | 9.7 kb | Proximal (<10kb) | 316 | |
| chr3:9,353,554–9,353,685 | 9.4 kb | Proximal (<10kb) | 220 | |
| chr3:9,362,788–9,363,525 | 37 bp | At TSS Multiome | 988 | |
| chr3:9,499,948–9,500,976 | 137.6 kb | Distal (>10kb) Multiome | 320 | |
| chr3:9,552,048–9,552,879 | 189.4 kb | Distal (>10kb) Multiome | 372 | |
| chr3:9,553,391–9,554,161 | 190.8 kb | Distal (>10kb) Multiome | 128 | |
| chr3:9,649,068–9,649,746 | 286.3 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the THUMPD3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.