Predicted to be involved in actin cytoskeleton organization. Predicted to be located in membrane. Predicted to be active in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THSD7B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THSD7B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THSD7B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:136,423,046–136,423,952 | 341.9 kb | Distal (>10kb) Multiome HiCAR | 547 | |
| chr2:136,758,431–136,758,643 | 6.9 kb | Proximal (<10kb) | 7 | |
| chr2:136,764,263–136,766,385 | at TSS | At TSS | 383 | |
| chr2:136,766,728–136,767,211 | 1.2 kb | Proximal (<10kb) | 22 | |
| chr2:136,920,829–136,922,354 | 156.5 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the THSD7B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.