Predicted to enable mRNA binding activity. Involved in mRNA export from nucleus and monocyte differentiation. Located in chromosome, telomeric region and nucleoplasm. Part of THO complex part of transcription export complex. Implicated in breast carcinoma. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for THOC5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = THOC5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of THOC5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:29,267,574–29,268,917 | 285.5 kb | Distal (>10kb) Multiome | 969 | |
| chr22:29,304,664–29,307,808 | 246.8 kb | Distal (>10kb) Multiome | 839 | |
| chr22:29,313,065–29,313,784 | 240.3 kb | Distal (>10kb) Multiome | 274 | |
| chr22:29,315,074–29,316,064 | 238.1 kb | Distal (>10kb) Multiome | 242 | |
| chr22:29,388,161–29,388,971 | 165.1 kb | Distal (>10kb) Multiome | 740 | |
| chr22:29,431,916–29,432,715 | 121.4 kb | Distal (>10kb) Multiome | 14 | |
| chr22:29,470,132–29,470,844 | 83.2 kb | Distal (>10kb) Multiome | 437 | |
| chr22:29,480,003–29,481,437 | 72.6 kb | Distal (>10kb) Multiome | 384 | |
| chr22:29,553,345–29,553,988 | 53 bp | At TSS Multiome | 837 | |
| chr22:29,580,084–29,581,520 | 27.4 kb | Distal (>10kb) Multiome | 856 | |
| chr22:29,603,006–29,604,162 | 49.8 kb | Distal (>10kb) Multiome | 803 | |
| chr22:29,766,399–29,767,654 | 213.4 kb | Distal (>10kb) Multiome | 837 | |
| chr22:29,837,985–29,838,559 | 284.7 kb | Distal (>10kb) Multiome | 690 |
Genomic view of the THOC5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.