The gene is a member of the transcription factor DP family. The encoded protein forms heterodimers with the E2F transcription factors resulting in transcriptional activation of cell cycle regulated genes. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TFDP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFDP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFDP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:141,737,813–141,739,101 | 290.4 kb | Distal (>10kb) Multiome | 924 | |
| chr3:141,796,843–141,798,274 | 231.2 kb | Distal (>10kb) Multiome | 349 | |
| chr3:141,875,535–141,877,500 | 152.0 kb | Distal (>10kb) Multiome | 796 | |
| chr3:142,028,372–142,028,698 | at TSS | At TSS | 256 | |
| chr3:142,148,774–142,150,028 | 120.9 kb | Distal (>10kb) Multiome | 751 | |
| chr3:142,224,898–142,225,944 | 196.9 kb | Distal (>10kb) Multiome | 837 |
Genomic view of the TFDP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.