Enables mitochondrial transcription factor activity. Involved in transcription initiation at mitochondrial promoter. Located in mitochondrial nucleoid. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TFB2M. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TFB2M upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TFB2M, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:246,416,783–246,419,459 | 148.8 kb | Distal (>10kb) Multiome | 407 | |
| chr1:246,506,470–246,507,681 | 59.0 kb | Distal (>10kb) Multiome | 631 | |
| chr1:246,565,796–246,567,114 | 199 bp | At TSS Multiome | 926 | |
| chr1:246,723,808–246,725,073 | 158.1 kb | Distal (>10kb) Multiome | 777 | |
| chr1:246,753,796–246,754,434 | 187.9 kb | Distal (>10kb) Multiome | 194 |
Genomic view of the TFB2M locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.