Transcription factors with Perturb-seq knockdown data for TEX30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:102,591,759–102,592,780 | 181.5 kb | Distal (>10kb) Multiome HiCAR | 578 | |
| chr13:102,596,004–102,597,912 | 176.9 kb | Distal (>10kb) Multiome HiCAR | 918 | |
| chr13:102,772,804–102,774,609 | 40 bp | At TSS Multiome | 683 | |
| chr13:102,777,730–102,778,079 | 4.0 kb | Proximal (<10kb) | 6 | |
| chr13:102,798,454–102,800,933 | 26.7 kb | Distal (>10kb) Multiome | 954 | |
| chr13:102,845,306–102,846,942 | 72.1 kb | Distal (>10kb) Multiome | 1003 | |
| chr13:103,039,032–103,039,885 | 265.7 kb | Distal (>10kb) Multiome | 153 | |
| chr13:103,067,554–103,069,132 | 294.6 kb | Distal (>10kb) Multiome | 223 |
Genomic view of the TEX30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.