This gene encodes a protein that is required for DNA double-strand break repair, chromosome synapsis, and meiotic recombination in spermatocytes. Male mice with a knockout of the orthologous gene are viable but sterile. Loss-of-function mutations in the orthologous mouse gene cause early meiotic arrest in spermatocytes, before the mid-pachytene stage. Naturally occurring mutations in this gene are associated with nonobstructive azoospermia. [provided by RefSeq, Apr 2017]
Transcription factors with Perturb-seq knockdown data for TEX15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEX15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEX15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:30,657,598–30,658,716 | 254.8 kb | Distal (>10kb) Multiome | 834 | |
| chr8:30,727,108–30,728,427 | 185.1 kb | Distal (>10kb) Multiome | 986 | |
| chr8:30,743,665–30,744,537 | 168.8 kb | Distal (>10kb) Multiome | 789 | |
| chr8:30,811,955–30,813,256 | 100.3 kb | Distal (>10kb) Multiome | 824 | |
| chr8:30,911,618–30,912,683 | 955 bp | At TSS Multiome | 460 | |
| chr8:30,912,801–30,913,145 | at TSS | At TSS | 298 | |
| chr8:30,919,030–30,919,275 | 6.0 kb | Proximal (<10kb) | 198 | |
| chr8:31,032,234–31,034,302 | 120.7 kb | Distal (>10kb) Multiome | 723 |
Genomic view of the TEX15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.