This gene product is a serine/threonine protein kinase that contains an N-terminal protein kinase domain and a C-terminal proline-rich domain. Its protein kinase domain is most closely related to those of the LIM motif-containing protein kinases (LIMKs). The encoded protein can phosphorylate myelin basic protein and histone in vitro. The testicular germ cell-specific expression and developmental pattern of expression of the mouse gene suggests that this gene plays an important role at and after the meiotic phase of spermatogenesis. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TESK1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TESK1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TESK1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:35,102,684–35,103,800 | 502.0 kb | Distal (>10kb) Multiome HiCAR | 886 | |
| chr9:35,406,111–35,407,050 | 198.6 kb | Distal (>10kb) Multiome | 145 | |
| chr9:35,424,217–35,425,184 | 180.6 kb | Distal (>10kb) Multiome | 171 | |
| chr9:35,489,223–35,490,919 | 115.3 kb | Distal (>10kb) Multiome | 918 | |
| chr9:35,603,584–35,606,173 | 1.1 kb | Proximal (<10kb) Multiome | 918 | |
| chr9:35,611,354–35,611,527 | 6.1 kb | Proximal (<10kb) | 103 | |
| chr9:35,645,821–35,647,298 | 40.6 kb | Distal (>10kb) Multiome | 734 | |
| chr9:35,657,275–35,659,114 | 52.8 kb | Distal (>10kb) Multiome | 1156 | |
| chr9:35,664,903–35,665,580 | 60.0 kb | Distal (>10kb) Multiome | 814 | |
| chr9:35,675,371–35,676,451 | 70.7 kb | Distal (>10kb) Multiome | 223 | |
| chr9:35,689,224–35,691,525 | 85.9 kb | Distal (>10kb) Multiome | 541 | |
| chr9:35,731,682–35,733,531 | 127.1 kb | Distal (>10kb) Multiome | 920 | |
| chr9:35,748,884–35,750,005 | 144.0 kb | Distal (>10kb) Multiome | 667 | |
| chr9:35,756,620–35,757,642 | 151.8 kb | Distal (>10kb) Multiome | 810 | |
| chr9:35,790,361–35,791,220 | 185.3 kb | Distal (>10kb) Multiome | 282 | |
| chr9:35,811,906–35,812,486 | 206.9 kb | Distal (>10kb) Multiome | 610 | |
| chr9:35,814,402–35,815,681 | 210.0 kb | Distal (>10kb) Multiome | 896 | |
| chr9:35,828,657–35,829,781 | 224.0 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the TESK1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.