Enables poly(A) RNA polymerase activity. Involved in several processes, including negative regulation of apoptotic process; negative regulation of cell population proliferation; and positive regulation of translation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TENT5B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TENT5B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TENT5B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:26,723,135–26,723,892 | 289.3 kb | Distal (>10kb) Multiome | 671 | |
| chr1:26,786,686–26,788,664 | 224.9 kb | Distal (>10kb) Multiome | 918 | |
| chr1:26,826,166–26,827,148 | 186.2 kb | Distal (>10kb) Multiome | 510 | |
| chr1:26,862,775–26,863,565 | 149.9 kb | Distal (>10kb) Multiome | 486 | |
| chr1:26,864,355–26,865,945 | 147.6 kb | Distal (>10kb) Multiome | 892 | |
| chr1:26,889,797–26,890,628 | 122.6 kb | Distal (>10kb) Multiome | 906 | |
| chr1:26,899,986–26,900,610 | 112.5 kb | Distal (>10kb) Multiome | 792 | |
| chr1:26,921,268–26,922,160 | 91.2 kb | Distal (>10kb) Multiome | 838 | |
| chr1:26,959,908–26,960,855 | 52.4 kb | Distal (>10kb) Multiome | 607 | |
| chr1:26,992,986–26,995,593 | 19.3 kb | Distal (>10kb) Multiome | 854 | |
| chr1:26,997,489–26,998,161 | 15.0 kb | Distal (>10kb) Multiome | 550 | |
| chr1:27,010,686–27,011,820 | 1.6 kb | Proximal (<10kb) Multiome | 379 | |
| chr1:27,012,151–27,013,639 | 162 bp | At TSS Multiome | 712 | |
| chr1:27,031,351–27,031,956 | 18.8 kb | Distal (>10kb) Multiome | 260 | |
| chr1:27,154,381–27,155,711 | 142.3 kb | Distal (>10kb) Multiome | 1038 | |
| chr1:27,233,894–27,235,362 | 221.6 kb | Distal (>10kb) Multiome | 807 |
Genomic view of the TENT5B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.