TELO2
telomere maintenance 2 | KIAA0683, TEL2, hCLK2

This gene encodes a protein that functions as an S-phase checkpoint protein in the cell cycle. The protein may also play a role in DNA repair.[provided by RefSeq, Mar 2009]

Biological processes 26 terms
'de novo' cotranslational protein folding (GO:0051083)Hsp90 protein binding (GO:0051879)Hsp90 protein binding (GO:0051879)chromosome, telomeric region (GO:0000781)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosol (GO:0005829)cytosol (GO:0005829)kinase binding (GO:0019900)membrane (GO:0016020)molecular adaptor activity (GO:0060090)nuclear body (GO:0016604)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of DNA damage checkpoint (GO:2000003)protein binding (GO:0005515)protein kinase binding (GO:0019901)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein stabilization (GO:0050821)protein-containing complex binding (GO:0044877)protein-containing complex binding (GO:0044877)protein-containing complex stabilizing activity (GO:0140777)telomeric repeat DNA binding (GO:0042162)
Expression (TPM)
TELO2 — as a Regulated Gene

TFs regulating TELO2 0 TFs

Transcription factors with Perturb-seq knockdown data for TELO2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TELO2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to TELO2

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TELO2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr16:1,300,823–1,301,358 192.3 kb Distal (>10kb) Multiome 419
chr16:1,308,686–1,309,923 184.2 kb Distal (>10kb) Multiome 953
chr16:1,331,603–1,332,817 161.3 kb Distal (>10kb) Multiome 492
chr16:1,333,312–1,334,056 159.8 kb Distal (>10kb) Multiome 271
chr16:1,342,604–1,343,805 150.2 kb Distal (>10kb) Multiome 560
chr16:1,351,418–1,352,242 141.5 kb Distal (>10kb) Multiome 733
chr16:1,378,844–1,380,439 113.6 kb Distal (>10kb) Multiome 782
chr16:1,408,010–1,408,819 85.0 kb Distal (>10kb) Multiome 546
chr16:1,413,643–1,415,278 78.6 kb Distal (>10kb) Multiome 661
chr16:1,420,269–1,421,402 72.5 kb Distal (>10kb) Multiome 897
chr16:1,474,566–1,475,411 18.3 kb Distal (>10kb) Multiome 915
chr16:1,492,797–1,493,962 38 bp At TSS Multiome 710
chr16:1,610,035–1,611,264 117.3 kb Distal (>10kb) Multiome 745
chr16:1,611,870–1,612,834 118.9 kb Distal (>10kb) Multiome 718
chr16:1,677,899–1,679,024 184.8 kb Distal (>10kb) Multiome 709
chr16:1,705,380–1,706,702 212.7 kb Distal (>10kb) Multiome 933
chr16:1,763,511–1,764,353 270.7 kb Distal (>10kb) Multiome 261
chr16:1,770,847–1,771,973 278.2 kb Distal (>10kb) Multiome HiCAR 485
chr16:1,772,565–1,774,049 280.0 kb Distal (>10kb) Multiome HiCAR 956
chr16:1,781,749–1,783,420 289.4 kb Distal (>10kb) Multiome 761

Genome Browser

Genomic view of the TELO2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr16:1,290,823 – 1,793,420
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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