The protein encoded by this gene belongs to the Tec family of non-receptor protein-tyrosine kinases containing a pleckstrin homology domain. Tec family kinases are involved in the intracellular signaling mechanisms of cytokine receptors, lymphocyte surface antigens, heterotrimeric G-protein coupled receptors, and integrin molecules. They are also key players in the regulation of the immune functions. Tec kinase is an integral component of T cell signaling and has a distinct role in T cell activation. This gene may be associated with myelodysplastic syndrome. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TEC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TEC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TEC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:48,015,887–48,017,756 | 253.2 kb | Distal (>10kb) Multiome | 714 | |
| chr4:48,126,799–48,128,119 | 142.0 kb | Distal (>10kb) Multiome | 526 | |
| chr4:48,268,963–48,270,705 | 66 bp | At TSS Multiome | 781 | |
| chr4:48,340,361–48,342,666 | 71.5 kb | Distal (>10kb) Multiome | 962 | |
| chr4:48,483,006–48,484,450 | 213.6 kb | Distal (>10kb) Multiome | 378 | |
| chr4:48,489,884–48,491,646 | 220.6 kb | Distal (>10kb) Multiome | 244 |
Genomic view of the TEC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.