Predicted to be involved in P granule organization; spermatid development; and transposable element silencing by piRNA-mediated DNA methylation. Predicted to be located in chromatoid body and pi-body. Predicted to be active in synapse. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TDRD5. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TDRD5 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TDRD5, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:179,081,467–179,083,301 | 509.6 kb | Distal (>10kb) Multiome HiCAR | 968 | |
| chr1:179,087,385–179,088,206 | 503.8 kb | Distal (>10kb) Multiome HiCAR | 194 | |
| chr1:179,293,131–179,294,199 | 297.9 kb | Distal (>10kb) Multiome | 884 | |
| chr1:179,365,435–179,366,459 | 225.7 kb | Distal (>10kb) Multiome | 811 | |
| chr1:179,586,188–179,586,937 | 5.2 kb | Proximal (<10kb) Multiome | 413 | |
| chr1:179,591,348–179,592,445 | 260 bp | At TSS Multiome | 401 | |
| chr1:179,702,681–179,703,716 | 111.6 kb | Distal (>10kb) Multiome | 163 | |
| chr1:179,742,680–179,744,798 | 151.6 kb | Distal (>10kb) Multiome | 322 | |
| chr1:179,788,146–179,788,608 | 196.9 kb | Distal (>10kb) Multiome | 55 | |
| chr1:179,814,386–179,815,656 | 223.3 kb | Distal (>10kb) Multiome | 543 | |
| chr1:179,877,712–179,878,194 | 286.2 kb | Distal (>10kb) Multiome | 604 | |
| chr1:179,881,882–179,883,626 | 291.0 kb | Distal (>10kb) Multiome | 1162 |
Genomic view of the TDRD5 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.