This gene encodes a protein containing a tudor domain that is thought to function in the suppression of transposable elements during spermatogenesis. The related protein in mouse forms a complex with piRNAs and Piwi proteins to promote methylation and silencing of target sequences. This gene was observed to be upregulated by ETS transcription factor ERG in prostate tumors. [provided by RefSeq, Sep 2018]
Transcription factors with Perturb-seq knockdown data for TDRD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TDRD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TDRD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:114,042,897–114,045,651 | 134.0 kb | Distal (>10kb) Multiome | 503 | |
| chr10:114,173,477–114,175,128 | 5.0 kb | Proximal (<10kb) Multiome | 842 | |
| chr10:114,179,165–114,179,646 | at TSS | At TSS | 116 | |
| chr10:114,239,111–114,240,320 | 60.4 kb | Distal (>10kb) Multiome | 417 | |
| chr10:114,303,821–114,305,401 | 125.6 kb | Distal (>10kb) Multiome | 424 | |
| chr10:114,402,845–114,405,341 | 224.5 kb | Distal (>10kb) Multiome | 410 |
Genomic view of the TDRD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.