Involved in negative regulation of osteoclast differentiation and osteoclast fusion. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCTA. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCTA upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCTA, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,120,575–49,121,282 | 291.4 kb | Distal (>10kb) Multiome | 765 | |
| chr3:49,132,603–49,133,965 | 278.7 kb | Distal (>10kb) Multiome | 652 | |
| chr3:49,166,057–49,166,586 | 246.0 kb | Distal (>10kb) Multiome | 622 | |
| chr3:49,170,896–49,171,950 | 241.0 kb | Distal (>10kb) Multiome | 781 | |
| chr3:49,276,912–49,277,398 | 135.3 kb | Distal (>10kb) Multiome | 291 | |
| chr3:49,339,607–49,340,853 | 72.2 kb | Distal (>10kb) Multiome | 1044 | |
| chr3:49,357,868–49,359,083 | 53.9 kb | Distal (>10kb) Multiome | 908 | |
| chr3:49,411,409–49,412,844 | 200 bp | At TSS Multiome | 899 | |
| chr3:49,422,179–49,422,905 | 10.2 kb | Distal (>10kb) Multiome | 453 | |
| chr3:49,428,857–49,429,869 | 17.1 kb | Distal (>10kb) Multiome | 712 | |
| chr3:49,461,484–49,462,134 | 49.4 kb | Distal (>10kb) Multiome | 207 | |
| chr3:49,468,926–49,470,930 | 57.9 kb | Distal (>10kb) Multiome | 919 | |
| chr3:49,539,369–49,540,584 | 127.6 kb | Distal (>10kb) Multiome | 628 | |
| chr3:49,553,618–49,555,244 | 142.1 kb | Distal (>10kb) Multiome | 710 |
Genomic view of the TCTA locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.