Predicted to be involved in muscle cell migration and signal transduction. Predicted to be located in cytoskeleton. Predicted to be part of cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCP11L2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCP11L2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCP11L2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:105,459,868–105,460,332 | 842.7 kb | Distal (>10kb) Multiome HiCAR | 58 | |
| chr12:106,138,295–106,140,144 | 163.6 kb | Distal (>10kb) Multiome | 675 | |
| chr12:106,247,023–106,248,967 | 54.6 kb | Distal (>10kb) Multiome | 593 | |
| chr12:106,301,702–106,303,676 | 802 bp | At TSS Multiome | 881 | |
| chr12:106,357,226–106,358,686 | 55.2 kb | Distal (>10kb) Multiome | 1122 |
Genomic view of the TCP11L2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.