The protein encoded by this gene is a molecular chaperone that is a member of the chaperonin containing TCP1 complex (CCT), also known as the TCP1 ring complex (TRiC). This complex consists of two identical stacked rings, each containing eight different proteins. Unfolded polypeptides enter the central cavity of the complex and are folded in an ATP-dependent manner. The complex folds various proteins, including actin and tubulin. Alternate transcriptional splice variants of this gene, encoding different isoforms, have been characterized. In addition, three pseudogenes that appear to be derived from this gene have been found. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for TCP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:159,168,575–159,170,383 | 620.3 kb | Distal (>10kb) Multiome HiCAR | 353 | |
| chr6:159,692,373–159,694,256 | 96.3 kb | Distal (>10kb) Multiome | 1061 | |
| chr6:159,726,454–159,728,172 | 62.5 kb | Distal (>10kb) Multiome | 1218 | |
| chr6:159,761,181–159,763,111 | 27.5 kb | Distal (>10kb) Multiome | 1026 | |
| chr6:159,788,809–159,791,272 | 58 bp | At TSS Multiome | 1073 | |
| chr6:159,968,449–159,970,213 | 179.3 kb | Distal (>10kb) Multiome | 961 |
Genomic view of the TCP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.