This gene encodes a member of the vitamin B12-binding protein family. This family of proteins, alternatively referred to as R binders, is expressed in various tissues and secretions. This plasma protein binds cobalamin and mediates the transport of cobalamin into cells. This protein and other mammalian cobalamin-binding proteins, such as transcobalamin I and gastric intrisic factor, may have evolved by duplication of a common ancestral gene. Alternative splicing results in multiple transcript variants.[provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TCN2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCN2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCN2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:30,326,296–30,327,463 | 280.1 kb | Distal (>10kb) Multiome | 565 | |
| chr22:30,356,495–30,357,510 | 250.3 kb | Distal (>10kb) Multiome | 824 | |
| chr22:30,386,775–30,387,972 | 219.8 kb | Distal (>10kb) Multiome | 499 | |
| chr22:30,392,372–30,393,155 | 214.3 kb | Distal (>10kb) Multiome | 209 | |
| chr22:30,396,849–30,397,353 | 210.2 kb | Distal (>10kb) Multiome | 385 | |
| chr22:30,422,945–30,424,825 | 183.1 kb | Distal (>10kb) Multiome | 1038 | |
| chr22:30,425,449–30,426,228 | 181.4 kb | Distal (>10kb) Multiome | 617 | |
| chr22:30,426,363–30,426,817 | 180.4 kb | Distal (>10kb) Multiome | 374 | |
| chr22:30,574,045–30,575,001 | 32.5 kb | Distal (>10kb) Multiome | 283 | |
| chr22:30,591,677–30,592,568 | 15.0 kb | Distal (>10kb) Multiome | 698 | |
| chr22:30,606,243–30,607,508 | 301 bp | At TSS Multiome | 507 | |
| chr22:30,634,485–30,636,231 | 28.5 kb | Distal (>10kb) Multiome | 611 | |
| chr22:30,667,348–30,668,634 | 60.7 kb | Distal (>10kb) Multiome | 590 | |
| chr22:30,694,739–30,695,381 | 87.6 kb | Distal (>10kb) Multiome | 278 | |
| chr22:30,802,592–30,803,363 | 195.8 kb | Distal (>10kb) Multiome | 898 |
Genomic view of the TCN2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.