This gene encodes a transcription factor that recognizes the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 promoter. The encoded protein is thought to be a transcriptional coactivator, enhancing the activity of transcription factors such as JUN and SP1. Mutations in this gene are associated with autism spectrum disorders. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2015]
Transcription factors with Perturb-seq knockdown data for TCF20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCF20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCF20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:42,070,303–42,071,253 | 272.8 kb | Distal (>10kb) Multiome | 833 | |
| chr22:42,074,171–42,074,703 | 269.2 kb | Distal (>10kb) Multiome | 178 | |
| chr22:42,079,194–42,080,293 | 263.8 kb | Distal (>10kb) Multiome | 872 | |
| chr22:42,090,032–42,091,609 | 252.7 kb | Distal (>10kb) Multiome | 910 | |
| chr22:42,269,385–42,271,172 | 72.9 kb | Distal (>10kb) Multiome | 751 | |
| chr22:42,343,251–42,344,201 | 16 bp | At TSS Multiome | 220 | |
| chr22:42,344,438–42,344,933 | 1.1 kb | Proximal (<10kb) Multiome | 162 | |
| chr22:42,365,301–42,366,142 | 21.9 kb | Distal (>10kb) Multiome | 197 | |
| chr22:42,368,263–42,369,908 | 25.7 kb | Distal (>10kb) Multiome | 592 | |
| chr22:42,437,555–42,438,618 | 94.2 kb | Distal (>10kb) Multiome | 501 | |
| chr22:42,444,134–42,444,723 | 100.8 kb | Distal (>10kb) Multiome | 574 | |
| chr22:42,499,840–42,501,072 | 156.8 kb | Distal (>10kb) Multiome | 356 | |
| chr22:42,519,544–42,520,134 | 176.2 kb | Distal (>10kb) Multiome | 330 | |
| chr22:42,553,476–42,554,267 | 210.2 kb | Distal (>10kb) Multiome | 514 | |
| chr22:42,581,750–42,582,381 | 238.5 kb | Distal (>10kb) Multiome | 290 | |
| chr22:42,614,291–42,616,423 | 271.7 kb | Distal (>10kb) Multiome | 1280 |
Genomic view of the TCF20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.