Predicted to enable RNA polymerase binding activity and transcription coregulator activity. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TCERG1L. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TCERG1L upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TCERG1L, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr10:131,048,652–131,049,557 | 262.5 kb | Distal (>10kb) Multiome | 185 | |
| chr10:131,279,836–131,280,788 | 31.4 kb | Distal (>10kb) Multiome | 17 | |
| chr10:131,310,649–131,313,035 | 914 bp | At TSS Multiome | 324 | |
| chr10:131,321,340–131,321,666 | 9.6 kb | Proximal (<10kb) | 13 | |
| chr10:131,453,017–131,454,385 | 142.4 kb | Distal (>10kb) Multiome | 319 | |
| chr10:131,874,962–131,875,578 | 563.4 kb | Distal (>10kb) Multiome HiCAR | 227 |
Genomic view of the TCERG1L locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.