Predicted to enable alpha-tubulin binding activity. Predicted to be involved in microtubule cytoskeleton organization; post-chaperonin tubulin folding pathway; and tubulin complex assembly. Predicted to be located in cytoskeleton. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBCEL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBCEL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBCEL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:120,527,165–120,527,924 | 496.6 kb | Distal (>10kb) Multiome HiCAR | 168 | |
| chr11:120,929,398–120,930,110 | 94.4 kb | Distal (>10kb) Multiome | 242 | |
| chr11:120,952,870–120,953,318 | 71.1 kb | Distal (>10kb) Multiome | 268 | |
| chr11:120,974,585–120,975,367 | 49.0 kb | Distal (>10kb) Multiome | 102 | |
| chr11:120,985,786–120,986,410 | 37.9 kb | Distal (>10kb) Multiome | 340 | |
| chr11:121,023,770–121,024,643 | 7 bp | At TSS Multiome | 720 | |
| chr11:121,245,998–121,246,994 | 222.2 kb | Distal (>10kb) Multiome | 99 | |
| chr11:121,282,691–121,283,424 | 259.0 kb | Distal (>10kb) Multiome | 96 | |
| chr11:121,292,065–121,293,479 | 268.6 kb | Distal (>10kb) Multiome | 859 |
Genomic view of the TBCEL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.