Cofactor C is one of four proteins (cofactors A, D, E, and C) involved in the pathway leading to correctly folded beta-tubulin from folding intermediates. Cofactors A and D are believed to play a role in capturing and stabilizing beta-tubulin intermediates in a quasi-native confirmation. Cofactor E binds to the cofactor D/beta-tubulin complex; interaction with cofactor C then causes the release of beta-tubulin polypeptides that are committed to the native state. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TBCC. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBCC upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBCC, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:42,451,208–42,454,840 | 294.3 kb | Distal (>10kb) Multiome | 808 | |
| chr6:42,547,405–42,547,886 | 198.4 kb | Distal (>10kb) Multiome | 570 | |
| chr6:42,563,541–42,564,644 | 182.1 kb | Distal (>10kb) Multiome | 1040 | |
| chr6:42,710,310–42,710,904 | 35.6 kb | Distal (>10kb) Multiome | 100 | |
| chr6:42,745,261–42,747,361 | 89 bp | At TSS Multiome | 1101 | |
| chr6:42,770,933–42,771,516 | 25.1 kb | Distal (>10kb) Multiome | 283 | |
| chr6:42,782,323–42,783,894 | 36.9 kb | Distal (>10kb) Multiome | 960 | |
| chr6:42,879,371–42,880,327 | 133.7 kb | Distal (>10kb) Multiome HiCAR | 982 | |
| chr6:42,890,329–42,891,383 | 144.7 kb | Distal (>10kb) Multiome | 1066 | |
| chr6:42,911,181–42,912,079 | 165.6 kb | Distal (>10kb) Multiome | 327 | |
| chr6:42,928,809–42,930,153 | 183.3 kb | Distal (>10kb) Multiome | 1111 | |
| chr6:42,960,347–42,961,147 | 214.6 kb | Distal (>10kb) Multiome | 597 | |
| chr6:42,978,475–42,979,742 | 233.1 kb | Distal (>10kb) Multiome | 914 | |
| chr6:42,983,832–42,985,046 | 238.3 kb | Distal (>10kb) Multiome | 737 | |
| chr6:43,013,264–43,014,790 | 268.0 kb | Distal (>10kb) Multiome | 874 | |
| chr6:43,020,970–43,021,878 | 275.4 kb | Distal (>10kb) Multiome | 766 |
Genomic view of the TBCC locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.