This gene encodes a protein with a TBC domain and functions as a Rab GTPase activating protein. The encoded protein is involved in the fusion of autophagosomes with endosomes and lysosomes. This gene was previously known as ornithine aminotransferase-like 1, but has no similarity to ornithine aminotransferase. [provided by RefSeq, Jan 2017]
Transcription factors with Perturb-seq knockdown data for TBC1D25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:48,475,845–48,476,469 | 63.6 kb | Distal (>10kb) Multiome | 613 | |
| chrX:48,508,766–48,509,247 | 30.8 kb | Distal (>10kb) Multiome | 400 | |
| chrX:48,521,369–48,522,158 | 18.0 kb | Distal (>10kb) Multiome | 519 | |
| chrX:48,539,185–48,540,294 | 82 bp | At TSS Multiome | 658 | |
| chrX:48,574,090–48,575,023 | 34.9 kb | Distal (>10kb) Multiome | 779 | |
| chrX:48,597,350–48,598,476 | 58.2 kb | Distal (>10kb) Multiome | 660 | |
| chrX:48,676,132–48,677,132 | 136.8 kb | Distal (>10kb) Multiome | 642 | |
| chrX:48,695,862–48,697,105 | 156.9 kb | Distal (>10kb) Multiome | 600 | |
| chrX:48,737,116–48,737,756 | 197.7 kb | Distal (>10kb) Multiome | 580 | |
| chrX:48,801,126–48,802,845 | 262.2 kb | Distal (>10kb) Multiome | 734 |
Genomic view of the TBC1D25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.