Enables GTPase activator activity and cadherin binding activity. Involved in positive regulation of GTPase activity. Located in several cellular components, including cytoplasmic vesicle; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TBC1D2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:97,982,380–97,985,451 | 270.9 kb | Distal (>10kb) Multiome | 994 | |
| chr9:98,056,283–98,057,271 | 199.0 kb | Distal (>10kb) Multiome | 868 | |
| chr9:98,087,291–98,088,183 | 167.9 kb | Distal (>10kb) Multiome | 281 | |
| chr9:98,118,693–98,119,508 | 136.5 kb | Distal (>10kb) Multiome | 752 | |
| chr9:98,191,695–98,193,531 | 62.6 kb | Distal (>10kb) Multiome | 795 | |
| chr9:98,218,786–98,219,246 | 36.6 kb | Distal (>10kb) Multiome HiCAR | 178 | |
| chr9:98,255,174–98,256,530 | 183 bp | At TSS Multiome | 905 | |
| chr9:98,263,843–98,264,035 | 8.2 kb | Proximal (<10kb) | 300 | |
| chr9:98,265,141–98,265,693 | 9.9 kb | Proximal (<10kb) Multiome | 26 | |
| chr9:98,280,310–98,281,125 | 25.1 kb | Distal (>10kb) Multiome | 235 | |
| chr9:98,315,414–98,316,053 | 60.1 kb | Distal (>10kb) Multiome | 373 |
Genomic view of the TBC1D2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.