Small G proteins of the RAB family (see MIM 179508) function in intracellular vesicle trafficking by switching from the GTP-bound state to the GDP-bound state with the assistance of guanine nucleotide exchange factors (GEFs; see MIM 609700) and GTPase-activating proteins (GAPs). TBC1D10B functions as a GAP for several proteins of the Rab family (Ishibashi et al., 2009 [PubMed 19077034]).[supplied by OMIM, Nov 2010]
Transcription factors with Perturb-seq knockdown data for TBC1D10B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBC1D10B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBC1D10B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:30,075,490–30,076,439 | 294.5 kb | Distal (>10kb) Multiome | 828 | |
| chr16:30,090,881–30,092,910 | 277.6 kb | Distal (>10kb) Multiome | 1101 | |
| chr16:30,095,557–30,096,839 | 274.2 kb | Distal (>10kb) Multiome | 824 | |
| chr16:30,122,728–30,123,578 | 247.2 kb | Distal (>10kb) Multiome | 718 | |
| chr16:30,182,759–30,183,865 | 187.1 kb | Distal (>10kb) Multiome | 547 | |
| chr16:30,334,526–30,335,777 | 35.1 kb | Distal (>10kb) Multiome | 486 | |
| chr16:30,354,854–30,355,978 | 15.1 kb | Distal (>10kb) Multiome | 1070 | |
| chr16:30,369,220–30,371,611 | 263 bp | At TSS Multiome | 818 | |
| chr16:30,377,495–30,379,532 | 7.9 kb | Proximal (<10kb) Multiome | 1025 | |
| chr16:30,394,422–30,396,098 | 24.7 kb | Distal (>10kb) Multiome | 941 | |
| chr16:30,400,026–30,401,048 | 30.1 kb | Distal (>10kb) Multiome | 839 | |
| chr16:30,406,974–30,408,429 | 37.0 kb | Distal (>10kb) Multiome | 908 | |
| chr16:30,417,414–30,418,576 | 47.6 kb | Distal (>10kb) Multiome | 543 | |
| chr16:30,429,571–30,430,773 | 59.7 kb | Distal (>10kb) Multiome | 1060 | |
| chr16:30,445,340–30,446,062 | 75.3 kb | Distal (>10kb) Multiome | 898 | |
| chr16:30,526,068–30,527,896 | 156.9 kb | Distal (>10kb) Multiome | 1004 | |
| chr16:30,534,370–30,535,460 | 164.4 kb | Distal (>10kb) Multiome | 957 | |
| chr16:30,557,913–30,558,847 | 188.0 kb | Distal (>10kb) Multiome | 1025 | |
| chr16:30,571,001–30,572,505 | 201.5 kb | Distal (>10kb) Multiome | 950 | |
| chr16:30,585,243–30,586,223 | 215.3 kb | Distal (>10kb) Multiome | 588 | |
| chr16:30,609,586–30,610,748 | 240.0 kb | Distal (>10kb) Multiome | 1030 | |
| chr16:30,634,070–30,634,986 | 263.9 kb | Distal (>10kb) Multiome | 907 | |
| chr16:30,650,029–30,651,831 | 280.2 kb | Distal (>10kb) Multiome | 992 | |
| chr16:30,657,638–30,659,894 | 287.8 kb | Distal (>10kb) Multiome | 1053 |
Genomic view of the TBC1D10B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.