Predicted to enable 3'-5'-DNA exonuclease activity. Predicted to be involved in DNA metabolic process. Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TATDN1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TATDN1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TATDN1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:124,371,408–124,373,569 | 166.3 kb | Distal (>10kb) Multiome | 891 | |
| chr8:124,425,336–124,426,470 | 112.9 kb | Distal (>10kb) Multiome | 332 | |
| chr8:124,473,813–124,475,636 | 64.3 kb | Distal (>10kb) Multiome | 970 | |
| chr8:124,528,920–124,529,115 | 10.0 kb | Proximal (<10kb) | 17 | |
| chr8:124,538,425–124,538,723 | 346 bp | At TSS | 377 | |
| chr8:124,538,847–124,539,474 | 31 bp | At TSS Multiome | 921 | |
| chr8:124,635,289–124,635,776 | 96.5 kb | Distal (>10kb) Multiome | 230 | |
| chr8:124,726,992–124,728,984 | 189.5 kb | Distal (>10kb) Multiome | 609 | |
| chr8:124,830,627–124,831,574 | 292.0 kb | Distal (>10kb) Multiome | 135 | |
| chr8:124,963,890–124,964,452 | 425.0 kb | Distal (>10kb) Multiome HiCAR | 165 | |
| chr8:124,997,595–124,999,115 | 459.3 kb | Distal (>10kb) Multiome HiCAR | 836 |
Genomic view of the TATDN1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.