This gene encodes an endopeptidase that cleaves specific substrates following aspartate residues. The encoded protein undergoes posttranslational autoproteolytic processing to generate alpha and beta subunits, which reassemble into the active alpha2-beta2 heterotetramer. It is required to cleave MLL, a protein required for the maintenance of HOX gene expression, and TFIIA, a basal transcription factor. Alternatively spliced transcript variants have been described, but their biological validity has not been determined. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TASP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TASP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TASP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:12,752,662–12,753,638 | 885.7 kb | Distal (>10kb) Multiome HiCAR | 154 | |
| chr20:12,753,782–12,754,273 | 884.8 kb | Distal (>10kb) Multiome HiCAR | 34 | |
| chr20:13,356,537–13,358,221 | 281.6 kb | Distal (>10kb) Multiome | 223 | |
| chr20:13,638,235–13,639,573 | 109 bp | At TSS Multiome | 858 | |
| chr20:13,784,410–13,785,713 | 146.1 kb | Distal (>10kb) Multiome | 1055 | |
| chr20:13,849,862–13,851,076 | 211.5 kb | Distal (>10kb) Multiome | 199 | |
| chr20:13,873,896–13,875,288 | 235.8 kb | Distal (>10kb) Multiome | 154 |
Genomic view of the TASP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.