Enables chromatin binding activity. Involved in protein localization to heterochromatin and transposable element silencing by heterochromatin formation. Located in heterochromatin and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TASOR. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TASOR upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TASOR, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:56,467,084–56,467,577 | 216.0 kb | Distal (>10kb) Multiome | 156 | |
| chr3:56,467,706–56,468,963 | 214.7 kb | Distal (>10kb) Multiome | 376 | |
| chr3:56,556,857–56,557,974 | 126.1 kb | Distal (>10kb) Multiome | 756 | |
| chr3:56,682,322–56,683,608 | 31 bp | At TSS Multiome | 963 | |
| chr3:56,782,366–56,782,841 | 99.4 kb | Distal (>10kb) Multiome | 265 | |
| chr3:56,801,406–56,802,556 | 118.8 kb | Distal (>10kb) Multiome | 717 | |
| chr3:56,823,361–56,824,198 | 140.5 kb | Distal (>10kb) Multiome | 160 | |
| chr3:56,874,031–56,874,571 | 191.2 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the TASOR locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.